Nature Communications (Jan 2017)

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

  • Yu-Sang Sabrina Yang,
  • Prabhani U. Atukorale,
  • Kelly D. Moynihan,
  • Ahmet Bekdemir,
  • Kavya Rakhra,
  • Li Tang,
  • Francesco Stellacci,
  • Darrell J. Irvine

DOI
https://doi.org/10.1038/ncomms14069
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Assessing nanomaterials at the single cell level has proven to be complicated due to the limitations of existing techniques. Here, the authors utilised single-cell mass cytometry by time-of-flight as a label-free technique to analyse nanoparticle distribution within cells.