Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

Xiaoyi Zhu; Qiang Huang; Anthony DiSpirito; Tri Vu; Qiangzhou Rong; Xiaorui Peng; Huaxin Sheng; Xiling Shen; Qifa Zhou; Laiming Jiang; Ulrike Hoffmann; Junjie Yao

doi:10.1038/s41377-022-00836-2

Light: Science & Applications (May 2022)

Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

Xiaoyi Zhu,
Qiang Huang,
Anthony DiSpirito,
Tri Vu,
Qiangzhou Rong,
Xiaorui Peng,
Huaxin Sheng,
Xiling Shen,
Qifa Zhou,
Laiming Jiang,
Ulrike Hoffmann,
Junjie Yao

Affiliations

Xiaoyi Zhu: Department of Biomedical Engineering, Duke University
Qiang Huang: Department of Biomedical Engineering, Duke University
Anthony DiSpirito: Department of Biomedical Engineering, Duke University
Tri Vu: Department of Biomedical Engineering, Duke University
Qiangzhou Rong: Department of Biomedical Engineering, Duke University
Xiaorui Peng: Department of Biomedical Engineering, Duke University
Huaxin Sheng: Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California
Xiling Shen: Department of Biomedical Engineering, Duke University
Qifa Zhou: Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California
Laiming Jiang: Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California
Ulrike Hoffmann: Department of Anesthesiology, Duke University
Junjie Yao: Department of Biomedical Engineering, Duke University

DOI: https://doi.org/10.1038/s41377-022-00836-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The ultrafast wide-field photoacoustic microscopy integrates novel light source, fast scanning mechanism, and machine learning enhancement, which allows high-speed tracking of whole-brain functions in action at capillary level.

Published in Light: Science & Applications

ISSN: 2047-7538 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Technology: Engineering (General). Civil engineering (General): Applied optics. Photonics; Science: Physics: Optics. Light
Website: https://www.nature.com/lsa/

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