Nature Communications (Jan 2023)
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation
- Zachary A. Hing,
- Janek S. Walker,
- Ethan C. Whipp,
- Lindsey Brinton,
- Matthew Cannon,
- Pu Zhang,
- Steven Sher,
- Casey B. Cempre,
- Fiona Brown,
- Porsha L. Smith,
- Claudio Agostinelli,
- Stefano A. Pileri,
- Jordan N. Skinner,
- Katie Williams,
- Hannah Phillips,
- Jami Shaffer,
- Larry P. Beaver,
- Alexander Pan,
- Kyle Shin,
- Charles T. Gregory,
- Gulcin H. Ozer,
- Selen A. Yilmaz,
- Bonnie K. Harrington,
- Amy M. Lehman,
- Lianbo Yu,
- Vincenzo Coppola,
- Pearlly Yan,
- Peggy Scherle,
- Min Wang,
- Philip Pitis,
- Chaoyi Xu,
- Kris Vaddi,
- Selina Chen-Kiang,
- Jennifer Woyach,
- James S. Blachly,
- Lapo Alinari,
- Yiping Yang,
- John C. Byrd,
- Robert A. Baiocchi,
- Bradley W. Blaser,
- Rosa Lapalombella
Affiliations
- Zachary A. Hing
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Janek S. Walker
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Ethan C. Whipp
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Lindsey Brinton
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Matthew Cannon
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Pu Zhang
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Steven Sher
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Casey B. Cempre
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Fiona Brown
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Porsha L. Smith
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Claudio Agostinelli
- Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Stefano A. Pileri
- European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)
- Jordan N. Skinner
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Katie Williams
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Hannah Phillips
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Jami Shaffer
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Larry P. Beaver
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Alexander Pan
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Kyle Shin
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Charles T. Gregory
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Gulcin H. Ozer
- Department of Biomedical Informatics, The Ohio State University
- Selen A. Yilmaz
- Department of Biomedical Informatics, The Ohio State University
- Bonnie K. Harrington
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Amy M. Lehman
- Center for Biostatistics, The Ohio State University
- Lianbo Yu
- Center for Biostatistics, The Ohio State University
- Vincenzo Coppola
- Department of Cancer Biology and Genetics, The Ohio State University
- Pearlly Yan
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Peggy Scherle
- Prelude Therapeutics
- Min Wang
- Prelude Therapeutics
- Philip Pitis
- Prelude Therapeutics
- Chaoyi Xu
- Prelude Therapeutics
- Kris Vaddi
- Prelude Therapeutics
- Selina Chen-Kiang
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Jennifer Woyach
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- James S. Blachly
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Lapo Alinari
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Yiping Yang
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- John C. Byrd
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Robert A. Baiocchi
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Bradley W. Blaser
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Rosa Lapalombella
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-022-35778-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.
