Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis

Yuan He; Renee Bouwstra; Valerie R. Wiersma; Mathilde de Jong; Harm Jan Lourens; Rudolf Fehrmann; Marco de Bruyn; Emanuele Ammatuna; Gerwin Huls; Tom van Meerten; Edwin Bremer

doi:10.1038/s41467-018-08013-z

Nature Communications (Feb 2019)

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis

Yuan He,
Renee Bouwstra,
Valerie R. Wiersma,
Mathilde de Jong,
Harm Jan Lourens,
Rudolf Fehrmann,
Marco de Bruyn,
Emanuele Ammatuna,
Gerwin Huls,
Tom van Meerten,
Edwin Bremer

Affiliations

Yuan He: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Renee Bouwstra: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Valerie R. Wiersma: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Mathilde de Jong: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Harm Jan Lourens: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Rudolf Fehrmann: Department of Medical Oncology, University of Groningen, University Medical Center Groningen (UMCG)
Marco de Bruyn: Department of Gynecological Oncology, University of Groningen, University Medical Center Groningen (UMCG)
Emanuele Ammatuna: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Gerwin Huls: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Tom van Meerten: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)
Edwin Bremer: Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG)

DOI: https://doi.org/10.1038/s41467-018-08013-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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CD47 is a promising new target in cancer immunotherapy and recently the pro-phagocytic signal SLAMF7 has been shown to have a crucial role in phagocytosis induced by CD47-blocking antibody in hematological tumors. In this study, the authors demonstrate that SLAMF7 expressed by cancer cells is not required for phagocytosis suggesting that, in contrast to CD47 expression, SLAMF7 should not be used as selection criterion for CD47-targeted therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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