THE INFLUENCE OF COLLOID SILVER NANO-PARTICLES UPON IMMUNOBIOLOGIC PROPERTIES OF PLAGUE MICROBE CAPSULAR ANTIGEN

Abstract

This study shows that Yersinia pestis capsular antigen F1 conjugated to the CS nano-particles demonstrates apparent immunogenic effects. When injected to the test animals it was able to stimulate the production of specific antibodies under smaller antigenic load, it caused activation of the genetic apparatus in the immune system cells, and it stimulated hyperplastic processes in the lymphoid organs. Solutions of CS plus antigens appeared to be stable and caused neither general nor local responses in the test animals; they were easy to make use of, thus demonstrating their potentialities to be exploited as adjuvants in immunologic practices.

Keywords

• yersinia pestis capsular antigen f1
• immunobiological properties
• adjuvant