Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats

Nobunao Ikewaki; Kadalraja Raghavan; Vidyasagar Devaprasad Dedeepiya; Suryaprakash Vaddi; Masaru Iwasaki; Rajappa Senthilkumar; Senthilkumar Preethy; Samuel JK Abraham

Clinical Immunology Communications (Dec 2021)

Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats

Nobunao Ikewaki,
Kadalraja Raghavan,
Vidyasagar Devaprasad Dedeepiya,
Suryaprakash Vaddi,
Masaru Iwasaki,
Rajappa Senthilkumar,
Senthilkumar Preethy,
Samuel JK Abraham

Affiliations

Nobunao Ikewaki: Dept. of Medical Life Science, Kyushu University of Health and Welfare, Japan; Institute of Immunology, Junsei Educational Institute, Nobeoka, Miyazaki, Japan
Kadalraja Raghavan: Research & Development Division, Sarvee Integra Private Limited, Chennai, India.; Dept. of Paediatric Neurology, Jesuit Antonyraj memorial Inter-disciplinary Centre for Advanced Rehabilitation and Education (JAICARE), Madurai, India
Vidyasagar Devaprasad Dedeepiya: Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India
Suryaprakash Vaddi: Department of Urology, Yashoda Hospitals, Hyderabad, India
Masaru Iwasaki: Centre for Advancing Clinical Research (CACR), University of Yamanashi - School of Medicine, Chuo, Japan.
Rajappa Senthilkumar: Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India
Senthilkumar Preethy: Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India
Samuel JK Abraham: Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India; Centre for Advancing Clinical Research (CACR), University of Yamanashi - School of Medicine, Chuo, Japan.; Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan; Corresponding Author: Dr. Samuel JK Abraham, University of Yamanashi, School of Medicine, Chuo, Japan, 3-8, Wakamatsu, Kofu, Yamanashi 400-0866, Japan, Phone: +81-55-235-7527

Journal volume & issue: Vol. 1
pp. 29 – 34

Abstract

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The beneficial immunomodulation effects of a biological response modifier glucan (BRMG) produced by two strains of Aureobasidium pullulans, AFO-202 and N-163, have already been reported. Herein, we compared their efficacy on immune-inflammatory parameters in Sprague Dawley (SD) rats. This study was performed on four groups of healthy SD rats, n=6 in each group: Group 1, euthanised on Day 0 for baseline values; Group 2, control (drinking water); Group 3, AFO-202 beta glucan, 200 mg/kg/day; and Group 4, N-163 beta glucan, 300 mg/kg/day. The neutrophil to lymphocyte ratio (NLR) decreased and leukocyte-to C-reactive protein ratio (LeCR) increased in Group 3 (AFO-202) at 15 and 29 days whereas the lymphocyte to C-reactive protein ratio (LCR) increased in group 4 (N-163), within the normal physiological range. These promising results warrant further investigations in larger numbers of healthy and diseased models to develop appropriate strategies for balancing immune system dysregulation.

Published in Clinical Immunology Communications

ISSN: 2772-6134 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.journals.elsevier.com/clinical-immunology-communications

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