Antimicrobial peptide nanoparticles coated with macrophage cell membrane for targeted antimicrobial therapy of sepsis

Zhizhen Meng; Luqi Pan; Songzan Qian; Xiao Yang; Lingling Pan; Runrun Chi; Jie Chen; Jingye Pan; Changcan Shi

Materials & Design (May 2023)

Antimicrobial peptide nanoparticles coated with macrophage cell membrane for targeted antimicrobial therapy of sepsis

Zhizhen Meng,
Luqi Pan,
Songzan Qian,
Xiao Yang,
Lingling Pan,
Runrun Chi,
Jie Chen,
Jingye Pan,
Changcan Shi

Affiliations

Zhizhen Meng: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China
Luqi Pan: Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China
Songzan Qian: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
Xiao Yang: Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China
Lingling Pan: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
Runrun Chi: School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
Jie Chen: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Corresponding authors at: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China (J. Chen and J. Pan) Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China (C. Shi).
Jingye Pan: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Corresponding authors at: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China (J. Chen and J. Pan) Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China (C. Shi).
Changcan Shi: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China; School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Joint Center of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China; Corresponding authors at: Department of Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China (J. Chen and J. Pan) Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China (C. Shi).

Journal volume & issue: Vol. 229
p. 111883

Abstract

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Sepsis is a serious life-threatening disease. Bacterial infection is one of the main causes of sepsis. Although etiopathogenesis is gradually understood, the treatment is still scarce. Mortality caused by sepsis is still challenge. Herein, macrophage membrane coated antimicrobial peptide nanoparticles (M−AMPNP) was explored based on the specific binding of bacterial recognition receptors on macrophage membrane to bacteria. M−AMPNP was used to treat sepsis caused by bacterial infection. In vivo results showed that M−AMPNP was effectively delivered and retained at the site of infection by intravenous injection, which reduced the level of inflammatory factors and ultimately gave infected mice a significant survival advantage. M−AMPNP provides a potential strategy for targeted therapy of sepsis.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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