An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone

Abstract

Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.

Keywords

• chemoenzymatic
• α-pyrone
• ketoreductase
• bioreduction
• rugulactone
• inhibitor