Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells

Sisi Jia; Siew Cheng Phua; Yuta Nihongaki; Yizeng Li; Michael Pacella; Yi Li; Abdul M. Mohammed; Sean Sun; Takanari Inoue; Rebecca Schulman

doi:10.1038/s41467-021-25890-z

Nature Communications (Sep 2021)

Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells

Sisi Jia,
Siew Cheng Phua,
Yuta Nihongaki,
Yizeng Li,
Michael Pacella,
Yi Li,
Abdul M. Mohammed,
Sean Sun,
Takanari Inoue,
Rebecca Schulman

Affiliations

Sisi Jia: Department of Chemical and Biomolecular Engineering, Johns Hopkins University
Siew Cheng Phua: Department of Cell Biology, Johns Hopkins University School of Medicine
Yuta Nihongaki: Department of Cell Biology, Johns Hopkins University School of Medicine
Yizeng Li: Department of Mechanical Engineering, Johns Hopkins University
Michael Pacella: Department of Chemical and Biomolecular Engineering, Johns Hopkins University
Yi Li: Department of Chemical and Biomolecular Engineering, Johns Hopkins University
Abdul M. Mohammed: Department of Chemical and Biomolecular Engineering, Johns Hopkins University
Sean Sun: Department of Mechanical Engineering, Johns Hopkins University
Takanari Inoue: Department of Cell Biology, Johns Hopkins University School of Medicine
Rebecca Schulman: Department of Chemical and Biomolecular Engineering, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-021-25890-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Mesoscale molecular assemblies on the cell surface integrate information and amplify signals. Here the authors integrate DNA nanotubes in a controlled manner with mammalian cells to act as sheer stress meters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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