Nature Communications (Dec 2021)
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
- Marco Bolis,
- Daniela Bossi,
- Arianna Vallerga,
- Valentina Ceserani,
- Manuela Cavalli,
- Daniela Impellizzieri,
- Laura Di Rito,
- Eugenio Zoni,
- Simone Mosole,
- Angela Rita Elia,
- Andrea Rinaldi,
- Ricardo Pereira Mestre,
- Eugenia D’Antonio,
- Matteo Ferrari,
- Flavio Stoffel,
- Fernando Jermini,
- Silke Gillessen,
- Lukas Bubendorf,
- Peter Schraml,
- Arianna Calcinotto,
- Eva Corey,
- Holger Moch,
- Martin Spahn,
- George Thalmann,
- Marianna Kruithof-de Julio,
- Mark A. Rubin,
- Jean-Philippe P. Theurillat
Affiliations
- Marco Bolis
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Daniela Bossi
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Arianna Vallerga
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Valentina Ceserani
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Manuela Cavalli
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Daniela Impellizzieri
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Laura Di Rito
- Computational Oncology Unit, Department of Oncology, Istituto di Richerche Farmacologiche ‘Mario Negri’ IRCCS
- Eugenio Zoni
- Department of Biomedical Research, University of Bern
- Simone Mosole
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Angela Rita Elia
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Andrea Rinaldi
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Ricardo Pereira Mestre
- Oncology Institute of Southern Switzerland
- Eugenia D’Antonio
- Oncology Institute of Southern Switzerland
- Matteo Ferrari
- Urology Department, Ente Ospedaliero Cantonale
- Flavio Stoffel
- Urology Department, Ente Ospedaliero Cantonale
- Fernando Jermini
- Urology Department, Ente Ospedaliero Cantonale
- Silke Gillessen
- Oncology Institute of Southern Switzerland
- Lukas Bubendorf
- Institute of Surgical Pathology, University Hospital Basel
- Peter Schraml
- Department of Pathology, University Hospital Zurich
- Arianna Calcinotto
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- Eva Corey
- Department of Urology, University of Washington
- Holger Moch
- Department of Pathology, University Hospital Zurich
- Martin Spahn
- Lindenhofspital Bern, Prostate Center Bern
- George Thalmann
- Department of Biomedical Research, University of Bern
- Marianna Kruithof-de Julio
- Department of Biomedical Research, University of Bern
- Mark A. Rubin
- Department of Biomedical Research, University of Bern
- Jean-Philippe P. Theurillat
- Faculty of Biomedical Sciences, Institute of Oncology Research, USI
- DOI
- https://doi.org/10.1038/s41467-021-26840-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progression.
