Environment International (Apr 2023)
The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults
- Mengge Liu,
- Tong Han,
- Yue Wu,
- Jingliang Cheng,
- Longjiang Zhang,
- Bing Zhang,
- Xi-Nian Zuo,
- Wenzhen Zhu,
- Shijun Qiu,
- Zuojun Geng,
- Xiaochu Zhang,
- Guangbin Cui,
- Quan Zhang,
- Yongqiang Yu,
- Hui Zhang,
- Bo Gao,
- Xiaojun Xu,
- Zhenwei Yao,
- Wen Qin,
- Meng Liang,
- Feng Liu,
- Lining Guo,
- Qiang Xu,
- Jilian Fu,
- Jiayuan Xu,
- Jie Tang,
- Nana Liu,
- Kaizhong Xue,
- Peng Zhang,
- Wei Li,
- Dapeng Shi,
- Caihong Wang,
- Jia-Hong Gao,
- Su Lui,
- Zhihan Yan,
- Feng Chen,
- Jiance Li,
- Jing Zhang,
- Wen Shen,
- Yanwei Miao,
- Junfang Xian,
- Le Yu,
- Kai Xu,
- Meiyun Wang,
- Zhaoxiang Ye,
- Wei-Hua Liao,
- Dawei Wang,
- Chunshui Yu
Affiliations
- Mengge Liu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Tong Han
- Department of Radiology, Tianjin Huanhu Hospital, 300350 Tianjin, China
- Yue Wu
- Department of Radiology, Huashan Hospital, Fudan University, 200040 Shanghai, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China
- Longjiang Zhang
- Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 210002 Nanjing, China
- Bing Zhang
- Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, 210008 Nanjing, China
- Xi-Nian Zuo
- IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875 Beijing, China; Institute of Psychology, Chinese Academy of Sciences, 100101 Beijing, China
- Wenzhen Zhu
- Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China
- Shijun Qiu
- Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 510405 Guangzhou, China
- Zuojun Geng
- Department of Medical Imaging, The Second Hospital of Hebei Medical University, 050000 Shijiazhuang, China
- Xiaochu Zhang
- Division of Life Science and Medicine, University of Science & Technology of China, 230027 Hefei, China
- Guangbin Cui
- Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, 710038 Xi'an, China
- Quan Zhang
- Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, 300162 Tianjin, China
- Yongqiang Yu
- Department of Radiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, China
- Hui Zhang
- Department of Radiology, The First Hospital of Shanxi Medical University, 030001 Taiyuan, China
- Bo Gao
- Department of Radiology, The Affiliated Hospital of Guizhou Medical University, 550004 Guiyang, China; Department of Radiology, Yantai Yuhuangding Hospital, 264000 Yantai, China
- Xiaojun Xu
- Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 310009 Hangzhou, China
- Zhenwei Yao
- Department of Radiology, Huashan Hospital, Fudan University, 200040 Shanghai, China
- Wen Qin
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Meng Liang
- School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, 300203 Tianjin, China
- Feng Liu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Lining Guo
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Qiang Xu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Jilian Fu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Jiayuan Xu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Jie Tang
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Nana Liu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Kaizhong Xue
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China
- Peng Zhang
- Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, 300060 Tianjin, China
- Wei Li
- Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, 300060 Tianjin, China
- Dapeng Shi
- Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, 450003 Zhengzhou, China
- Caihong Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China
- Jia-Hong Gao
- Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, 100871 Beijing, China
- Su Lui
- Department of Radiology, the Center for Medical Imaging, West China Hospital of Sichuan University, 610041 Chengdu, China
- Zhihan Yan
- Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325027 Wenzhou, China
- Feng Chen
- Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), 570311 Haikou, China
- Jiance Li
- Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, China
- Jing Zhang
- Department of Magnetic Resonance, Lanzhou University Second Hospital, 730030 Lanzhou, China; Gansu Province Clinical Research Center for Functional and Molecular Imaging, 730030 Lanzhou, China
- Wen Shen
- Department of Radiology, Tianjin First Center Hospital, 300192 Tianjin, China
- Yanwei Miao
- Department of Radiology, The First Affiliated Hospital of Dalian Medical University, 116011 Dalian, China
- Junfang Xian
- Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 100730 Beijing, China
- Le Yu
- Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, China
- Kai Xu
- Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 221006 Xuzhou, China
- Meiyun Wang
- Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, 450003 Zhengzhou, China
- Zhaoxiang Ye
- Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, 300060 Tianjin, China
- Wei-Hua Liao
- Department of Radiology, Xiangya Hospital, Central South University, 410008 Changsha, China; Molecular Imaging Research Center of Central South University, 410008 Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008 Changsha, China; Corresponding authors.
- Dawei Wang
- Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, China; Corresponding authors.
- Chunshui Yu
- Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, 300052 Tianjin, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 200031 Shanghai, China; Corresponding authors.
- Journal volume & issue
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Vol. 174
p. 107905
Abstract
Background: Urbanicity refers to the conditions that are particular to urban areas and is a growing environmental challenge that may affect hippocampus and neurocognition. This study aimed to investigate the effects of the average pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities as well as the sensitive age windows of the urbanicity effects. Participants and methods: We included 5,390 CHIMGEN participants (3,538 females; age: 23.69 ± 2.26 years, range: 18–30 years). Pre-adulthood urbanicity of each participant was defined as the average value of annual night-time light (NL) or built-up% from age 0–18, which were extracted from remote-sensing satellite data based on annual residential coordinates of the participants. The hippocampal subfield volumes were calculated based on structural MRI and eight neurocognitive measures were assessed. The linear regression was applied to investigate the associations of pre-adulthood NL with hippocampal subfield volumes and neurocognitive abilities, mediation models were used to find the underlying pathways among urbanicity, hippocampus and neurocognition, and distributed lag models were used to identify sensitive age windows of urbanicity effect. Results: Higher pre-adulthood NL was associated with greater volumes in the left (β = 0.100, 95%CI: [0.075, 0.125]) and right (0.078, [0.052, 0.103]) fimbria and left subiculum body (0.045, [0.020, 0.070]) and better neurocognitive abilities in information processing speed (-0.212, [-0.240, −0.183]), working memory (0.085, [0.057, 0.114]), episodic memory (0.107, [0.080, 0.135]), and immediate (0.094, [0.065, 0.123]) and delayed (0.087, [0.058, 0.116]) visuospatial recall, and hippocampal subfield volumes and visuospatial memory showed bilateral mediations for the urbanicity effects. Urbanicity effects were greatest on the fimbria in preschool and adolescence, on visuospatial memory and information processing from childhood to adolescence and on working memory after 14 years. Conclusion: These findings improve our understanding of the impact of urbanicity on hippocampus and neurocognitive abilities and will benefit for designing more targeted intervention for neurocognitive improvement.
