Nature Communications (Dec 2017)

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

  • Yu Zhang,
  • Xian Guo,
  • Wanyao Yan,
  • Yan Chen,
  • Mengxiang Ke,
  • Cheng Cheng,
  • Xiuqin Zhu,
  • Weili Xue,
  • Qiaoqiao Zhou,
  • Ling Zheng,
  • Shun Wang,
  • Bin Wu,
  • Xinran Liu,
  • Liang Ma,
  • Lianqi Huang,
  • Kun Huang

DOI
https://doi.org/10.1038/s41467-017-02355-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.