NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

Abstract

Metabolomics deals with uncovering and characterizing metabolites present in a biological system, and is a leading omics discipline as it provides the nearest link to the biological phenotype. Within food and nutrition, metabolomics applied to fecal samples and bio-fluids has become an important tool to obtain insight into how food and food components may exert gut-modulating effects. This review aims to highlight how nuclear magnetic resonance (NMR)-based metabolomics in food and nutrition science may help us get beyond where we are today in understanding foods’ inherent, or added, biofunctionalities in relation to gut health.

Keywords

• gut-host associations
• saccharolytic activity
• unfavorable metabolites
• calcium