Effect of topical adrenalin on the development of myringosclerosis after myringotomy

Abstract

INTRODUCTION: In this study, the effects of adrenaline bleeding control on myringosclerosis (MS) development after myringotomy in experimental model were investigated. METHODS: Sixteen Wistar-Albino healthy male rats were used in the experiment. The right and left ear of each rat were accepted as the control group and the ears were divided into 4 groups. Group 1: 8 rats, examined 48 hours after Miringotomy, with adrenaline applied to the left ear. Group 2: 8 rats, examined 120 hours after miringotomy, with adrenaline applied to the left ear. Group 3: 8 rats, examined 48 hours after miringotomy, with saline applied to the right ear. Group 4: 8 rats, examined 120 hours after miringotomy, with saline applied to the right ear.At the end of the experiment, ears of rats were examined otomicroscopically and histopathologically. RESULTS: There was no statistically significant difference between the groups in terms of vascular dilatation, congestion, inflammatory cell, leukocyte count, mast cell degranulation, connective tissue increase and sclerosis. DISCUSSION AND CONCLUSION: In this study, we have investigated the view that hemorrhage from the margins of myringotomy and the development of inflammatory cell migration to the myringotomy site and the development of inflammation may contribute to the development of myringosclerosis. It is important that the local administration of adrenaline, by virtue of its vasoconstrictor effect, may reduce the amount of bleeding and thereby prevent the development of myringosclerosis. However, there is a need for wider working groups to determine its statistical significance.

Keywords

• myringotomy
• myringosclerosis
• adrenalin
• saline