The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Robert E. Turnbull; Louise Fairall; Almutasem Saleh; Emma Kelsall; Kyle L. Morris; T. J. Ragan; Christos G. Savva; Aditya Chandru; Christopher J. Millard; Olga V. Makarova; Corinne J. Smith; Alan M. Roseman; Andrew M. Fry; Shaun M. Cowley; John W. R. Schwabe

doi:10.1038/s41467-020-17078-8

Nature Communications (Jun 2020)

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Robert E. Turnbull,
Louise Fairall,
Almutasem Saleh,
Emma Kelsall,
Kyle L. Morris,
T. J. Ragan,
Christos G. Savva,
Aditya Chandru,
Christopher J. Millard,
Olga V. Makarova,
Corinne J. Smith,
Alan M. Roseman,
Andrew M. Fry,
Shaun M. Cowley,
John W. R. Schwabe

Affiliations

Robert E. Turnbull: Leicester Institute of Structural and Chemical Biology, University of Leicester
Louise Fairall: Leicester Institute of Structural and Chemical Biology, University of Leicester
Almutasem Saleh: Leicester Institute of Structural and Chemical Biology, University of Leicester
Emma Kelsall: Department of Molecular and Cell Biology, University of Leicester
Kyle L. Morris: School of Life Sciences, University of Warwick
T. J. Ragan: Leicester Institute of Structural and Chemical Biology, University of Leicester
Christos G. Savva: Leicester Institute of Structural and Chemical Biology, University of Leicester
Aditya Chandru: Department of Molecular and Cell Biology, University of Leicester
Christopher J. Millard: Leicester Institute of Structural and Chemical Biology, University of Leicester
Olga V. Makarova: Department of Molecular and Cell Biology, University of Leicester
Corinne J. Smith: School of Life Sciences, University of Warwick
Alan M. Roseman: Division of Molecular and Cellular Function, University of Manchester
Andrew M. Fry: Department of Molecular and Cell Biology, University of Leicester
Shaun M. Cowley: Department of Molecular and Cell Biology, University of Leicester
John W. R. Schwabe: Leicester Institute of Structural and Chemical Biology, University of Leicester

DOI: https://doi.org/10.1038/s41467-020-17078-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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