Molecular mechanism of Arp2/3 complex inhibition by Arpin

Fred E. Fregoso; Trevor van Eeuwen; Gleb Simanov; Grzegorz Rebowski; Malgorzata Boczkowska; Austin Zimmet; Alexis M. Gautreau; Roberto Dominguez

doi:10.1038/s41467-022-28112-2

Nature Communications (Feb 2022)

Molecular mechanism of Arp2/3 complex inhibition by Arpin

Fred E. Fregoso,
Trevor van Eeuwen,
Gleb Simanov,
Grzegorz Rebowski,
Malgorzata Boczkowska,
Austin Zimmet,
Alexis M. Gautreau,
Roberto Dominguez

Affiliations

Fred E. Fregoso: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
Trevor van Eeuwen: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
Gleb Simanov: Laboratoire de Biologie Structurale de la Cellule, CNRS, Institut Polytechnique de Paris
Grzegorz Rebowski: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
Malgorzata Boczkowska: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
Austin Zimmet: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
Alexis M. Gautreau: Laboratoire de Biologie Structurale de la Cellule, CNRS, Institut Polytechnique de Paris
Roberto Dominguez: Department of Physiology and Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-022-28112-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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The Arp2/3 complex inhibitor Arpin controls cell migration by interrupting a feedback loop involving Rac-WAVE-Arp2/3 complex Here, the authors use structural, biochemical, and cellular studies to reveal Arpin’s mechanism of inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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