Nature Communications (Nov 2018)
Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
- Tarik Hadi,
- Ludovic Boytard,
- Michele Silvestro,
- Dornazsadat Alebrahim,
- Samson Jacob,
- Jordyn Feinstein,
- Krista Barone,
- Wes Spiro,
- Susan Hutchison,
- Russell Simon,
- Debra Rateri,
- Florence Pinet,
- David Fenyo,
- Mark Adelman,
- Kathryn J. Moore,
- Holger K. Eltzschig,
- Alan Daugherty,
- Bhama Ramkhelawon
Affiliations
- Tarik Hadi
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Ludovic Boytard
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Michele Silvestro
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Dornazsadat Alebrahim
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Samson Jacob
- Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
- Jordyn Feinstein
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Krista Barone
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Wes Spiro
- Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine
- Susan Hutchison
- Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine
- Russell Simon
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Debra Rateri
- Department of Physiology and Saha Cardiovascular Research Center, University of Kentucky
- Florence Pinet
- University of Lille, Inserm U1167, Institut Pasteur de Lille
- David Fenyo
- Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
- Mark Adelman
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- Kathryn J. Moore
- Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine
- Holger K. Eltzschig
- Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston
- Alan Daugherty
- Department of Physiology and Saha Cardiovascular Research Center, University of Kentucky
- Bhama Ramkhelawon
- Division of Vascular Surgery, Department of Surgery, New York University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-07495-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of the matrix metalloproteinase MMP-3 by VSMCs and subsequent matrix degradation in AAA lesions.
