مجله دانشکده پزشکی اصفهان (Mar 2012)
Comparison of Serum Selenium Levels in Patients with Hodgkin's Disease and Healthy People
Abstract
Background: Selenium is important in preventing the production of oxidants and free radicals within active cells of our body, particularly immune system cells and T-cells. It also prevents the incidence of neoplastic mutation. We thus tried to investigate serum selenium levels in patients with Hodgkin's disease. Methods: This study was conducted on 43 patients with Hodgkin's disease before implementing any treatment and in staging steps of the disease as the case group. In addition, the control group included 30 healthy individual from the siblings of the patients with similar age range, place, climate, and nutritional conditions. Findings: The mean selenium levels in patients with Hodgkin's disease and healthy individuals were 50.914 and 72.120 micrograms per liter, respectively. The 2 groups were hence significantly different (P = 0.0001). The mean selenium levels in patients with Hodgkin's disease were significantly different among different types of pathology (subtype) and advanced stages of the disease (staging) (P = 0.001). Conclusion: The results showed that decreased serum selenium was clearer in advanced stages of disease (staging) or in more malignant pathology subtypes.
