Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia

Abstract

Large-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pathologic forms of erythrocytes. Participation of bone marrow mesenchimal stem cells and increased content of neural cells-precursors in central nervous system in conditions of oxygen deficiency are revealed. Failure of the given adaptation mechanisms of “deep reserve” in severe hypoxia which manifests in the development of encephalopathy and disadaptation of hemopoietic tissue is revealed.

Keywords

• гипоксия
• энцефалопатия
• гемопоэз
• гемопоэзиндуцирующее микроокружение
• мезенхимальные стволовые клетки
• нейральные клетки-предшественники
• hypoxia
• encephalopathy
• hemopoiesis
• hemopoiesis-induced micro-environment
• mesenchimal stem cells
• neural cells-precursors