Cosmetics (Jan 2022)
Cosmetic Potential of a Recombinant 50 kDa Protein
- Nesma Aly,
- Emilie Benoit,
- Jean-Luc Chaubard,
- Kavyasree Chintalapudi,
- Soojin Choung,
- Monique de Leeuw,
- Matthew Diaz,
- Dan Dueppen,
- Bryce Ferraro,
- Valerie Fischetti,
- Evan Gassaway,
- Isabelle Hansenne-Cervantes,
- Arjan Heeres,
- Christina Karas,
- Mohamed Khan,
- Jonathan M. Kral,
- Srujana Lam,
- Richel Lartey,
- Mencius Leonard,
- Stanley W. Lue,
- Joshua McDaniel,
- Kevin Ramirez,
- Brenna Rauw,
- Kelly A. Raymond,
- Catherine Roggero-Lovisi,
- Scott Rubin,
- Kristin Ruebling-Jass,
- Zoë Spiegelhoff,
- Monica Celise Stewart,
- Shashwat Vajpeyi,
- Alejandro Vicente,
- Kathleen E. Vincent,
- Jing Wang,
- David Williamson,
- Zhihao Yu,
- Lixin Dai
Affiliations
- Nesma Aly
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Emilie Benoit
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Jean-Luc Chaubard
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Kavyasree Chintalapudi
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Soojin Choung
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Monique de Leeuw
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Matthew Diaz
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Dan Dueppen
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Bryce Ferraro
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Valerie Fischetti
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Evan Gassaway
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Isabelle Hansenne-Cervantes
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Arjan Heeres
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Christina Karas
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Mohamed Khan
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Jonathan M. Kral
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Srujana Lam
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Richel Lartey
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Mencius Leonard
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Stanley W. Lue
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Joshua McDaniel
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Kevin Ramirez
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Brenna Rauw
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Kelly A. Raymond
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Catherine Roggero-Lovisi
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Scott Rubin
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Kristin Ruebling-Jass
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Zoë Spiegelhoff
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Monica Celise Stewart
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Shashwat Vajpeyi
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Alejandro Vicente
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Kathleen E. Vincent
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Jing Wang
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- David Williamson
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Zhihao Yu
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- Lixin Dai
- Modern Meadow, Inc., 111 Ideation Way, Suite 100, Nutley, NJ 07110, USA
- DOI
- https://doi.org/10.3390/cosmetics9010008
- Journal volume & issue
-
Vol. 9,
no. 1
p. 8
Abstract
Collagen and its derivative proteins have been widely used as a major component for cosmetic formulations as a natural ingredient and moisturizer. Most commercially available collagens are animal-derived collagen type I and other forms of collagen, such as type III collagen, are far less prevalent in animals, making extraction and purification extremely difficult and expensive. Here, we report the production of a 50 kDa protein produced in yeast that is 100% identical to the N-terminus of the human type III collagen. This recombinant protein has a larger molecular weight than most incumbent recombinant collagen proteins available for personal care applications. We report the industrialization of both the fermentation and purification processes to produce a final recombinant protein product. This final protein product was shown to be safe for general applications to human skin and compatible with common formulation protocols, including ethanol-based formulations. This recombinant collagen type III protein was also shown to uniquely stimulate both collagen type I and type III production and secretion by primary human dermal fibroblasts. The unique combination of biostimulation, compatibility with beauty product formulations and demonstrated commercial production, make this novel recombinant type III collagen a good candidate for broad application in the cosmetics industry.
Keywords
