A Case Report of a Novel Balanced Reciprocal Translocation t(2;14)(q11;q24) in a Young Woman with Two Pregnancy Losses

Abstract

Reciprocal chromosome translocations, especially balanced rearrangements are known to be one of the main causes of recurrent miscarriage. In this case report, we performed the clinical and cytogenetic analysis on a young couple with two pregnancy losses. Though the couple had a normal clinical study, the cytogenetic analysis revealed a balanced reciprocal translocation of t(2;14)(q11;q24) whereas the husband has a normal karyotype of 46,XY. Indeed based on the literature, this is the first report of t(2;14)(q11;q24) related to pregnancy loss. Therefore, cytogenetic tests are recommended for couples with a history of miscarriage more than twice.

Keywords

• Recurrent miscarriage
• Balanced translocation
• t(2
• 14)