BMC Cancer (Dec 2012)

Association of p21 SNPs and risk of cervical cancer among Chinese women

  • Wang Ning,
  • Wang Shizhuo,
  • Zhang Qiao,
  • Lu Yanming,
  • Wei Heng,
  • Li Wei,
  • Zhang Shulan,
  • Yin Duo,
  • Ou Yangling

DOI
https://doi.org/10.1186/1471-2407-12-589
Journal volume & issue
Vol. 12, no. 1
p. 589

Abstract

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Abstract Background The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and other untested p21 SNPs in the risk of cervical cancer in a Chinese population. Methods We genotyped five p21 SNPs (rs762623, rs2395655, rs1801270, rs3176352, and rs1059234) using peripheral blood DNA from 393 cervical cancer patients and 434 controls. Results The frequency of the rs1801270 A allele in patients (0.421) was significantly lower than that in controls (0.494, p = 0.003). The frequency of the rs3176352 C allele in cases (0.319) was significantly lower than that in controls (0.417, p Conclusions We show an association between the p21 SNP rs1801270A allele and a decreased risk for cervical cancer in a population of Chinese women. The AGT haplotype formed by three p21 SNPs in LD (rs1801270, rs3176352 and rs1059234) also provided a protective effect in development of cervical cancer in this population.

Keywords