Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach

Colleen X. Muñoz; Evan C. Johnson; Laura J. Kunces; Amy L. McKenzie; Michael Wininger; Cory L. Butts; Aaron Caldwell; Adam Seal; Brendon P. McDermott; Jakob Vingren; Abigail T. Colburn; Skylar S. Wright; Virgilio Lopez III; Lawrence E. Armstrong; Elaine C. Lee

doi:10.3390/nu12051276

Nutrients (Apr 2020)

Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach

Colleen X. Muñoz,
Evan C. Johnson,
Laura J. Kunces,
Amy L. McKenzie,
Michael Wininger,
Cory L. Butts,
Aaron Caldwell,
Adam Seal,
Brendon P. McDermott,
Jakob Vingren,
Abigail T. Colburn,
Skylar S. Wright,
Virgilio Lopez III,
Lawrence E. Armstrong,
Elaine C. Lee

Affiliations

Colleen X. Muñoz: Department of Health Sciences, University of Hartford, West Hartford, CT 06117, USA
Evan C. Johnson: Division of Kinesiology & Health, University of Wyoming, Laramie, WY 82071, USA
Laura J. Kunces: Onegevity Health, New York, NY 10019, USA
Amy L. McKenzie: Virta Health, San Francisco, CA 94105, USA
Michael Wininger: Department of Health Sciences, University of Hartford, West Hartford, CT 06117, USA
Cory L. Butts: Department of Health Promotion & Human Performance Weber State University, University of Arkansas, Fayetteville, AR 72701, USA
Aaron Caldwell: Department of Health Promotion & Human Performance Weber State University, University of Arkansas, Fayetteville, AR 72701, USA
Adam Seal: Department of Health Promotion & Human Performance Weber State University, University of Arkansas, Fayetteville, AR 72701, USA
Brendon P. McDermott: Department of Health Promotion & Human Performance Weber State University, University of Arkansas, Fayetteville, AR 72701, USA
Jakob Vingren: Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
Abigail T. Colburn: Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA
Skylar S. Wright: Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA
Virgilio Lopez III: Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA
Lawrence E. Armstrong: Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA
Elaine C. Lee: Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA

DOI: https://doi.org/10.3390/nu12051276
Journal volume & issue: Vol. 12, no. 5
p. 1276

Abstract

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We investigated the impact of nutrient intake on hydration biomarkers in cyclists before and after a 161 km ride, including one hour after a 650 mL water bolus consumed post-ride. To control for multicollinearity, we chose a clustering-based, machine learning statistical approach. Five hydration biomarkers (urine color, urine specific gravity, plasma osmolality, plasma copeptin, and body mass change) were configured as raw- and percent change. Linear regressions were used to test for associations between hydration markers and eight predictor terms derived from 19 nutrients merged into a reduced-dimensionality dataset through serial k-means clustering. Most predictor groups showed significant association with at least one hydration biomarker: (1) Glycemic Load + Carbohydrates + Sodium, (2) Protein + Fat + Zinc, (3) Magnesium + Calcium, (4) Pinitol, (5) Caffeine, (6) Fiber + Betaine, and (7) Water; potassium + three polyols, and mannitol + sorbitol showed no significant associations with any hydration biomarker. All five hydration biomarkers were associated with at least one nutrient predictor in at least one configuration. We conclude that in a real-life scenario, some nutrients may serve as mediators of body water, and urine-specific hydration biomarkers may be more responsive to nutrient intake than measures derived from plasma or body mass.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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