WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Woo-Jeong Jeong; Jong-Chan Park; Woo-Shin Kim; Eun Ji Ro; Soung Hoo Jeon; Sang-Kyu Lee; Young Nyun Park; Do Sik Min; Kang-Yell Choi

doi:10.1038/s41467-018-08230-6

Nature Communications (Jan 2019)

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Woo-Jeong Jeong,
Jong-Chan Park,
Woo-Shin Kim,
Eun Ji Ro,
Soung Hoo Jeon,
Sang-Kyu Lee,
Young Nyun Park,
Do Sik Min,
Kang-Yell Choi

Affiliations

Woo-Jeong Jeong: Translational Research Center for Protein Function Control, Yonsei University
Jong-Chan Park: Translational Research Center for Protein Function Control, Yonsei University
Woo-Shin Kim: Translational Research Center for Protein Function Control, Yonsei University
Eun Ji Ro: Translational Research Center for Protein Function Control, Yonsei University
Soung Hoo Jeon: Translational Research Center for Protein Function Control, Yonsei University
Sang-Kyu Lee: Translational Research Center for Protein Function Control, Yonsei University
Young Nyun Park: Department of Pathology, Yonsei University College of Medicine
Do Sik Min: Translational Research Center for Protein Function Control, Yonsei University
Kang-Yell Choi: Translational Research Center for Protein Function Control, Yonsei University

DOI: https://doi.org/10.1038/s41467-018-08230-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor in liver cancer

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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