Turning antibodies off and on again using a covalently tethered blocking peptide

Affiliations

Michael Brasino: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Eli Wagnell: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Sean Hamilton: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Srivathsan Ranganathan: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Michelle M. Gomes: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Bruce Branchaud: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University
Bradley Messmer: Abreos Biosciences
Stuart D. Ibsen: Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University

Abstract

Modulation of antibody binding is developed through a photo-cleavable tether that is covalently conjugated to the antibody and to a blocking peptide.