Experimental Evaluation of Hemostatic Agents and Powdered Sorbent Effectiveness on the Dynamics of Blood Aggregate State Regulation using the Method of Thromboelastography

Abstract

Background: This article presents the results of an experimental study on the effect of hemostatic agents (Hemostatic collagen sponge, Tachocomb, Surgitamp and granular sorbent Molselect G-50) on the system regulating the aggregate state of the blood (SRASB) using piezoelectric thromboelastography (TEG). Methods and Results: The study involved 18 healthy men aged between 21 and 43 years [29.0 (25.0-32.5) years] with normal indicators of the SRASB. In the first series of experiments, TEG of the blood was recorded without the addition of the test material (the control stage). At the second stage of the experiment, the hemostatic properties of the Hemostatic collagen sponge, Tachocomb, hemostatic gauze Surgitamp and granular sorbent Molselect G-50 were studied. In vitro experimental studies to assess the effect of hemostatic agents and granular sorbent on the SRASB using piezoelectric TEG have shown that the use of Hemostatic collagen sponge, Tachocomb, Surgitamp, and the granular sorbent Molselect G-50 convincingly affects all links of the thrombosis process. However, Surgitamp and the granular sorbent Molselect G-50 show the greatest influence on such important indicators as TBC and MCD, which gives reason to conclude they are effective in clinical use in surgical practice.

Keywords

• thromboelastography
• aggregate state of the blood
• hemostatic agents
• granular sorbents