Nanog promotes stem-like traits of glioblastoma cells

Yuan Ye; Mengsi Zhang; Guangning Yan; Qinghua Ma; Zexuan Yan; ,Lihong Wang; Kaidi Yang; Deyu Guo

doi:10.2741/4907

Frontiers in Bioscience-Landmark (Oct 2020)

Nanog promotes stem-like traits of glioblastoma cells

Yuan Ye,
Mengsi Zhang,
Guangning Yan,
Qinghua Ma,
Zexuan Yan,
,Lihong Wang,
Kaidi Yang,
Deyu Guo

Affiliations

Yuan Ye: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
Mengsi Zhang: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
Guangning Yan: Department of Pathology, General hospital of southern theatre command, People’s Liberation Army, Guangzhou, China
Qinghua Ma: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
Zexuan Yan: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
,Lihong Wang: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
Kaidi Yang: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
Deyu Guo: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China

DOI: https://doi.org/10.2741/4907
Journal volume & issue: Vol. 26, no. 3
pp. 552 – 565

Abstract

Read online

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in the pluripotency of embryonic stem cells (ESCs) and the induction of malignancy in cancer stem-like cells (CSCs). Bioinformatic analysis revealed that NANOG may be associated with the development of stem-like traits in GBM. Forced expression of NANOG markedly increased the expression of cancer stem cell markers and promoted the sphere formation and migration of GBM cells. Nanog enhanced the expression of SHH which is required for the maintenance of the positive feedback loop of Hedgehog signaling pathway. Treatment of GBM cells with SANT-1 and GANT61 significantly reduced the tumor progression. These data support a view that reduction of Nanog might have therapeutic benefits in GBM.

Published in Frontiers in Bioscience-Landmark

ISSN: 2768-6701 (Print); 2768-6698 (Online)
Publisher: IMR Press
Country of publisher: Singapore
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General)
Website: https://www.imrpress.com/journal/FBL

About the journal

Abstract

Keywords