Nanomaterial-Based Tumor Photothermal Immunotherapy

Abstract

Peng Xu, Feng Liang The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of ChinaCorrespondence: Feng Liang Email [email protected]: In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a promising therapeutic modality and technique for cancer tumor ablation. In addition to killing tumor cells directly through heat, PTT also can induce immunogenic cell death (ICD) to activate the whole-body anti-tumor immune response, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. When used in combination with immunotherapy, the efficacy of nanomaterial-based PTT can be improved. This article summarized the mechanism of nanomaterial-based PTT against cancer and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response. Moreover, we reviewed recent advances of nanomaterial-based photothermal immunotherapy and discussed challenges and future outlook.Keywords: nanomaterials, cell death mechanism of PTT, tumor microenvironment, immunogenic cell death, photothermal immunotherapy

Keywords

• nanomaterials
• photothermal therapy
• tumor microenvironment
• immunogenic cell death
• photothermal immunotherapy