Importance of Serum Adropin Levels in Ischemic Stroke: A Prospective Clinical Study

Abstract

Aim:Stroke should be diagnosed quickly and accurately in emergency settings. This study investigated serum adropin levels as a novel biomarker in the diagnostic value of ischemic stroke.Materials and Methods:A prospective cross-sectional study was conducted in a tertiary university hospital. Serum adropin levels were measured at the time of the first arrival in ischemic stroke patients (n=46) and healthy control (n=45). In the ischemic stroke group, blood samples were retaken 72 h after arrival.Results:There was a significant difference between the ischemic stroke group and the control group regarding adropin values at arrival (2.67+0.63 vs. 2.34+0.69, respectively p=0.032). There was no significant difference between the other groups in terms of arrival values (p>0.05). Logistic regression analysis revealed a statistically significant difference between the ischemic stroke and control groups (odds ratio: 2.23; 95% confidence interval: 1.140-4.360, p=0.019). In the ischemic stroke group, the adropin level was statistically significantly decreased on the third day compared with the arrival (p=0.041). The adropin levels predicted ischemic stroke patients with 58.7% sensitivity and 59.4% specificity with the 2.49 ng/mL cut-off value (area under the curve=0.635).Conclusion:In this study, high serum adropin levels can be thought to be supportive in the diagnostic value of ischemic stroke.

Keywords

• adropin
• ischemic stroke
• emergency department
• biomarker