The Relationship between Seru miR-340-5p, STING Levels and Disease Condition and Prognosis in Elderly Patients with Acute Ischemic Stroke

Abstract

Objective To investigate the relationship between serum miR-340-5p and stimulator of interferon gene (STING) levels in elderly patients with acute ischemic stroke and their condition and prognosis. Methods A total of 113 elderly patients with acute ischemic stroke admitted to Handan Central Hospital from May 2020 to May 2022 were selected as the study group, and 113 normal healthy patients during the same period were selected as the control group, according to the neurological impairment was assessed according to the National Institutes of Health Stroke Scale (NIHSS) score on the day of admission ( moderate > mild (P<0.05). There were 74 patients with good prognosis and 39 patients with poor prognosis. Serum STING level and NIHSS score at admission in the poor prognosis group were higher than those in the good prognosis group (P<0.05), while serum miR-340-5p level was lower than those in the good prognosis group (P<0.05). Multivariate logistic regression analysis showed that serum miR-340-5p was the protective factor for prognosis (P<0.05), and serum STING and NIHSS scores were the risk factors (P<0.05). ROC curve showed that the combined prognostic area of serum miR-340-5p and STING was greater than that predicted by each index alone (P<0.05). Conclusion The expression levels of serum miR-340-5p and STING can both reflect the condition of elderly patients with acute ischemic stroke, and have certain clinical value in prognostic prediction.

Keywords

• mir-340-5p
• stimulator of interferon gene
• acute ischemic stroke
• prognosis