Extranodal Biphenotypic Non-Hodgkin Lymphoma of the Popliteal Cavity: A Case Report and Review of Literature

Giulia A. Restivo; Lara Mussolin; Paolo D’Angelo; Angelica Zin; Martina Pigazzi; Elisa Carraro; Emanuele S. G. D’Amore; Marta Pillon; Piero Farruggia

doi:10.3390/diagnostics12071649

Diagnostics (Jul 2022)

Extranodal Biphenotypic Non-Hodgkin Lymphoma of the Popliteal Cavity: A Case Report and Review of Literature

Giulia A. Restivo,
Lara Mussolin,
Paolo D’Angelo,
Angelica Zin,
Martina Pigazzi,
Elisa Carraro,
Emanuele S. G. D’Amore,
Marta Pillon,
Piero Farruggia

Affiliations

Giulia A. Restivo: Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, Italy
Lara Mussolin: Clinic of Pediatric Hemato-Oncology, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy
Paolo D’Angelo: Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, 90127 Palermo, Italy
Angelica Zin: Institute of Pediatric Research-Fondazione Città della Speranza, 35127 Padova, Italy
Martina Pigazzi: Clinic of Pediatric Hemato-Oncology, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy
Elisa Carraro: Clinic of Pediatric Hemato-Oncology, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy
Emanuele S. G. D’Amore: Department of Pathology, San Bortolo Hospital, 36100 Vicenza, Italy
Marta Pillon: Clinic of Pediatric Hemato-Oncology, Department of Women’s and Children’s Health, University of Padova, 35128 Padova, Italy
Piero Farruggia: Department of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, 90127 Palermo, Italy

DOI: https://doi.org/10.3390/diagnostics12071649
Journal volume & issue: Vol. 12, no. 7
p. 1649

Abstract

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Primary soft-tissue lymphoma (PSTL) is a rare extranodal non-Hodgkin lymphoma, characterized by a mass growing within soft-tissue, which is connective tissue, adipose tissue, and skeletal muscle. Here, we describe a case of biphenotypic lymphoblastic lymphoma arising from soft tissue of the popliteal fossa in an 11-year-old boy. A pediatric review about PSTL revealed that anaplastic large cell lymphoma is the most common histological type and a biphenotypic lymphoblastic lymphoma has not yet been reported in childhood. Lymphoma should always be considered in patients presenting with a soft-tissue mass, and a comprehensive immunohistochemical evaluation, including B-cell, T-cell, and myeloid markers, is needed to make a correct diagnosis and establish the most suitable treatment.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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