Nature Communications (Dec 2020)
Genetic architecture of host proteins involved in SARS-CoV-2 infection
- Maik Pietzner,
- Eleanor Wheeler,
- Julia Carrasco-Zanini,
- Johannes Raffler,
- Nicola D. Kerrison,
- Erin Oerton,
- Victoria P. W. Auyeung,
- Jian’an Luan,
- Chris Finan,
- Juan P. Casas,
- Rachel Ostroff,
- Steve A. Williams,
- Gabi Kastenmüller,
- Markus Ralser,
- Eric R. Gamazon,
- Nicholas J. Wareham,
- Aroon D. Hingorani,
- Claudia Langenberg
Affiliations
- Maik Pietzner
- MRC Epidemiology Unit, University of Cambridge
- Eleanor Wheeler
- MRC Epidemiology Unit, University of Cambridge
- Julia Carrasco-Zanini
- MRC Epidemiology Unit, University of Cambridge
- Johannes Raffler
- Institute of Computational Biology, Helmholtz Zentrum München – German Research Center for Environmental Health
- Nicola D. Kerrison
- MRC Epidemiology Unit, University of Cambridge
- Erin Oerton
- MRC Epidemiology Unit, University of Cambridge
- Victoria P. W. Auyeung
- MRC Epidemiology Unit, University of Cambridge
- Jian’an Luan
- MRC Epidemiology Unit, University of Cambridge
- Chris Finan
- Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London
- Juan P. Casas
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Rachel Ostroff
- SomaLogic, Inc.
- Steve A. Williams
- SomaLogic, Inc.
- Gabi Kastenmüller
- Institute of Computational Biology, Helmholtz Zentrum München – German Research Center for Environmental Health
- Markus Ralser
- The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute
- Eric R. Gamazon
- MRC Epidemiology Unit, University of Cambridge
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge
- Aroon D. Hingorani
- Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-19996-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Finding effective treatments for COVID-19 depends upon understanding genetic regulation of proteins involved in SARS-CoV-2 infection and host response. Here, the authors identify genetic variants linked to expression of such proteins, data which could lead to the discovery of therapeutic targets.
