Signet-ring cell carcinoma of the caecum: A case report

Maissae Rahaoui, MD; Fakhrddine Amri, MD; Noura Seghrouchni, MD; Oumayma El Eulj, MD; Abdelkrim Zazour, MD; Hajar Koulali, MD; Ouiam Elmqaddem, MD; Amal Bennani, MD; Zahi Ismaili, MD; Ghizlane Kharrasse, MD

Radiology Case Reports (Jan 2024)

Signet-ring cell carcinoma of the caecum: A case report

Maissae Rahaoui, MD,
Fakhrddine Amri, MD,
Noura Seghrouchni, MD,
Oumayma El Eulj, MD,
Abdelkrim Zazour, MD,
Hajar Koulali, MD,
Ouiam Elmqaddem, MD,
Amal Bennani, MD,
Zahi Ismaili, MD,
Ghizlane Kharrasse, MD

Affiliations

Maissae Rahaoui, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco; Corresponding author.
Fakhrddine Amri, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Noura Seghrouchni, MD: Department of Pathology, Mohammed VI University Hospital, Oujda, Morocco
Oumayma El Eulj, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Abdelkrim Zazour, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Hajar Koulali, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Ouiam Elmqaddem, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Amal Bennani, MD: Department of Pathology, Mohammed VI University Hospital, Oujda, Morocco
Zahi Ismaili, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco
Ghizlane Kharrasse, MD: Department of Hepato-Gastroenterology, Mohammed VI University Hospital, Oujda, Morocco; Digestive Disease Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morrocco

Journal volume & issue: Vol. 19, no. 1
pp. 24 – 28

Abstract

Read online

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, with adenocarcinomas being the most frequent type. Signet ring cell carcinoma (SRCC) is a very rare subtype of adenocarcinoma, it commonly occurs in the stomach. However, other digestive localizations are possible including the colon, rectum, and gallbladder. Herein, we report a rare case of a metastatic caecal SRCC in a young male patient, presented to our department for abdominal diffuse pain and distention evolving for 3 months, associated with remarkable weight loss and asthenia. The clinical examination revealed abundant ascites and abdominal tenderness. Laboratory tests showed an elevated C-reactive protein at 35 mg/l (normal value: 13 g/dl), increased carcinoembryonic antigen (CEA) levels, as well as CA 19-9 and CA-125.The abdominal scan showed irregular and asymmetrical thickening with peripheral speculation of the caecum measuring 2.1 cm *5.8 cm. Additionally, adjacent adenopathies, abundant ascites, and peritoneal carcinomatosis were observed to be associated with suspicious bilateral pulmonary nodules and micronodules. The colonoscopy identified a bulging ulcerative tumor of the ileocecal valve extended to the ileum. Further histologic examination confirmed the presence of signet-ring cell carcinoma. The patient was referred to the medical oncology department to initiate palliative chemotherapy following a multidisciplinary consultation meeting. We can underline that SRCC of the caecum is a rare entity with a bad prognosis. Usually, the diagnosis is made at late stages due to the lack of obvious symptoms earlier.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

About the journal

Abstract

Keywords