Nature Communications (Feb 2020)

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

  • Pradeep Ramalingam,
  • Michael G. Poulos,
  • Elisa Lazzari,
  • Michael C. Gutkin,
  • David Lopez,
  • Christopher C. Kloss,
  • Michael J. Crowley,
  • Lizabeth Katsnelson,
  • Ana G. Freire,
  • Matthew B. Greenblatt,
  • Christopher Y. Park,
  • Jason M. Butler

DOI
https://doi.org/10.1038/s41467-020-14478-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 20

Abstract

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Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administration of Stem Cell Growth Factor SCGFa.