Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

Hongxia Li; Emily B. Harrison; Huizhong Li; Koichi Hirabayashi; Jing Chen; Qi-Xiang Li; Jared Gunn; Jared Weiss; Barbara Savoldo; Joel S. Parker; Chad V. Pecot; Gianpietro Dotti; Hongwei Du

doi:10.1038/s41467-022-29647-0

Nature Communications (Apr 2022)

Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

Hongxia Li,
Emily B. Harrison,
Huizhong Li,
Koichi Hirabayashi,
Jing Chen,
Qi-Xiang Li,
Jared Gunn,
Jared Weiss,
Barbara Savoldo,
Joel S. Parker,
Chad V. Pecot,
Gianpietro Dotti,
Hongwei Du

Affiliations

Hongxia Li: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Emily B. Harrison: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Huizhong Li: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Koichi Hirabayashi: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jing Chen: Crown Bioscience Inc
Qi-Xiang Li: Crown Bioscience Inc
Jared Gunn: Crown Bioscience Inc
Jared Weiss: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Barbara Savoldo: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Joel S. Parker: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Chad V. Pecot: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Gianpietro Dotti: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Hongwei Du: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-022-29647-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. Here the authors design B7-H3 targeting CAR-T cells engineered to express the chemokine receptor CCR2b, and show improved accumulation in the brain and enhanced anti-tumor activity in preclinical models of lung cancer brain metastases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal