Intestinal epithelial CGAS dampens inflammation by upregulating autophagy

Abstract

The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation. In this punctum, we discuss our novel finding that in the intestinal epithelium, CGAS binds to BECN1 (beclin 1) to subsequently induce macroautophagy/autophagy and dampen inflammation.

Keywords

• beclin 1
• colitis
• ibd
• lc3
• macroautophagy