Nature Communications (Aug 2021)
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
- Sandra S. Ring,
- Jovana Cupovic,
- Lucas Onder,
- Mechthild Lütge,
- Christian Perez-Shibayama,
- Cristina Gil-Cruz,
- Elke Scandella,
- Angelina De Martin,
- Urs Mörbe,
- Fabienne Hartmann,
- Robert Wenger,
- Matthias Spiegl,
- Andrej Besse,
- Weldy V. Bonilla,
- Felix Stemeseder,
- Sarah Schmidt,
- Klaus K. Orlinger,
- Philippe Krebs,
- Burkhard Ludewig,
- Lukas Flatz
Affiliations
- Sandra S. Ring
- Institute of Immunobiology, Kantonsspital St.Gallen
- Jovana Cupovic
- Institute of Immunobiology, Kantonsspital St.Gallen
- Lucas Onder
- Institute of Immunobiology, Kantonsspital St.Gallen
- Mechthild Lütge
- Institute of Immunobiology, Kantonsspital St.Gallen
- Christian Perez-Shibayama
- Institute of Immunobiology, Kantonsspital St.Gallen
- Cristina Gil-Cruz
- Institute of Immunobiology, Kantonsspital St.Gallen
- Elke Scandella
- Institute of Immunobiology, Kantonsspital St.Gallen
- Angelina De Martin
- Institute of Immunobiology, Kantonsspital St.Gallen
- Urs Mörbe
- Institute of Immunobiology, Kantonsspital St.Gallen
- Fabienne Hartmann
- Institute of Immunobiology, Kantonsspital St.Gallen
- Robert Wenger
- Department of Plastic Reconstructive Surgery, Kantonsspital St. Gallen
- Matthias Spiegl
- Department of Plastic Reconstructive Surgery, Kantonsspital St. Gallen
- Andrej Besse
- Department of Medical Oncology and Hematology, Kantonsspital St.Gallen
- Weldy V. Bonilla
- Division of Experimental Virology, Department of Biomedicine, University of Basel
- Felix Stemeseder
- Hookipa Pharma Inc.
- Sarah Schmidt
- Hookipa Pharma Inc.
- Klaus K. Orlinger
- Hookipa Pharma Inc.
- Philippe Krebs
- Institute of Pathology, University of Berne
- Burkhard Ludewig
- Institute of Immunobiology, Kantonsspital St.Gallen
- Lukas Flatz
- Institute of Immunobiology, Kantonsspital St.Gallen
- DOI
- https://doi.org/10.1038/s41467-021-25057-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a preclinical model of melanoma.
