Nature Communications (Dec 2017)
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
- Mayumi Kitagawa,
- Pei-Ju Liao,
- Kyung Hee Lee,
- Jasmine Wong,
- See Cheng Shang,
- Noriaki Minami,
- Oltea Sampetrean,
- Hideyuki Saya,
- Dai Lingyun,
- Nayana Prabhu,
- Go Ka Diam,
- Radoslaw Sobota,
- Andreas Larsson,
- Pär Nordlund,
- Frank McCormick,
- Sujoy Ghosh,
- David M. Epstein,
- Brian W. Dymock,
- Sang Hyun Lee
Affiliations
- Mayumi Kitagawa
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- Pei-Ju Liao
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- Kyung Hee Lee
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- Jasmine Wong
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- See Cheng Shang
- Department of Pharmacy, National University of Singapore
- Noriaki Minami
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Oltea Sampetrean
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Hideyuki Saya
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Dai Lingyun
- School of Biological Sciences, Nanyang Technological University
- Nayana Prabhu
- School of Biological Sciences, Nanyang Technological University
- Go Ka Diam
- School of Biological Sciences, Nanyang Technological University
- Radoslaw Sobota
- Institute of Molecular and Cell Biology, A*STAR
- Andreas Larsson
- School of Biological Sciences, Nanyang Technological University
- Pär Nordlund
- School of Biological Sciences, Nanyang Technological University
- Frank McCormick
- UCSF Helen Diller Family Comprehensive Cancer Center
- Sujoy Ghosh
- Department of Cardiovascular and Metabolic Research, Biomedical Biotechnology Research Institute, North Carolina Central University
- David M. Epstein
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- Brian W. Dymock
- Department of Pharmacy, National University of Singapore
- Sang Hyun Lee
- Program in Cancer & Stem Cell Biology, Duke-NUS Medical School
- DOI
- https://doi.org/10.1038/s41467-017-02287-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells.
