A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes

Abstract

Indolizine-2-carbaldehydes are important precursors for indolizine synthesis, however, their efficient construction remains challenging. Here, a recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of 1,2,3-trisubstituted indolizine-2-carbaldehydes is reported, via [3+2] annulations of acyl pyridines and α,β-unsaturated aldehydes.