Hypothalamus and amyotrophic lateral sclerosis: potential implications in sleep disorders

Valentina Gnoni; Valentina Gnoni; Stefano Zoccolella; Stefano Zoccolella; Alessia Giugno; Daniele Urso; Daniele Urso; Ludovica Tamburrino; Ludovica Tamburrino; Marco Filardi; Marco Filardi; Giancarlo Logroscino; Giancarlo Logroscino

doi:10.3389/fnagi.2023.1193483

Frontiers in Aging Neuroscience (Jul 2023)

Hypothalamus and amyotrophic lateral sclerosis: potential implications in sleep disorders

Valentina Gnoni,
Valentina Gnoni,
Stefano Zoccolella,
Stefano Zoccolella,
Alessia Giugno,
Daniele Urso,
Daniele Urso,
Ludovica Tamburrino,
Ludovica Tamburrino,
Marco Filardi,
Marco Filardi,
Giancarlo Logroscino,
Giancarlo Logroscino

Affiliations

Valentina Gnoni: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Valentina Gnoni: Department of Neurosciences, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, United Kingdom
Stefano Zoccolella: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Stefano Zoccolella: Neurology Unit, San Paolo Hospital, Azienda Sanitaria Locale (ASL) Bari, Bari, Italy
Alessia Giugno: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Daniele Urso: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Daniele Urso: Department of Neurosciences, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, United Kingdom
Ludovica Tamburrino: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Ludovica Tamburrino: Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy
Marco Filardi: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Marco Filardi: Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy
Giancarlo Logroscino: Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione “Card. G. Panico,”Tricase, Italy
Giancarlo Logroscino: Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy

DOI: https://doi.org/10.3389/fnagi.2023.1193483
Journal volume & issue: Vol. 15

Abstract

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects both motor and non-motor functions, including sleep regulation. Emerging evidence suggests that the hypothalamus, a brain region that plays a critical role in sleep-wake regulation, may be involved in the pathogenesis of ALS-related sleep disturbances. In this review, we have summarized results of studies on sleep disorders in ALS published between 2000 and 2023. Thereafter, we examined possible mechanisms by which hypothalamic dysfunctions may contribute to ALS-related sleep disturbances. Achieving a deeper understanding of the relationship between hypothalamic dysfunction and sleep disturbances in ALS can help improve the overall management of ALS and reduce the burden on patients and their families.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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