Participation of PI-3′-kinase signaling pathway in determining structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Abstract

Leukocytes aggregation ability from blood of healthy donors and type 1diabetes mellitus patients and molecular mechanisms of signal transduction through glycoprotein receptors involving phosphatidylinositol-3′-kinase, which influence polymerization of actin cytoskeleton of the studied cells were studies. This is a key problem in ensuring the leukocytes migration ability.

Keywords

• neutrophilic granulocytes
• mononuclear leukocytes
• lectin-induced aggregation
• phosphatidylinositol-3′-kinase