Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao; Xianfeng Xia; Xiayi Xu; Kevin Kai Chung Leung; Aliza Rai; Yingrui Deng; Boguang Yang; Huasheng Lai; Xin Peng; Peng Shi; Honglu Zhang; Philip Wai Yan Chiu; Liming Bian

doi:10.1038/s41467-021-27463-6

Nature Communications (Dec 2021)

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao,
Xianfeng Xia,
Xiayi Xu,
Kevin Kai Chung Leung,
Aliza Rai,
Yingrui Deng,
Boguang Yang,
Huasheng Lai,
Xin Peng,
Peng Shi,
Honglu Zhang,
Philip Wai Yan Chiu,
Liming Bian

Affiliations

Pengchao Zhao: Department of Biomedical Engineering, The Chinese University of Hong Kong
Xianfeng Xia: Department of Endoscopy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
Xiayi Xu: Department of Biomedical Engineering, The Chinese University of Hong Kong
Kevin Kai Chung Leung: Department of Surgery, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
Aliza Rai: Department of Surgery, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
Yingrui Deng: Department of Biomedical Engineering, The Chinese University of Hong Kong
Boguang Yang: Department of Biomedical Engineering, The Chinese University of Hong Kong
Huasheng Lai: Department of Surgery, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
Xin Peng: Department of Biomedical Engineering, The Chinese University of Hong Kong
Peng Shi: School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology
Honglu Zhang: School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology
Philip Wai Yan Chiu: Department of Biomedical Engineering, The Chinese University of Hong Kong
Liming Bian: School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology

DOI: https://doi.org/10.1038/s41467-021-27463-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The development of a drug delivery system capable of prolonged retention in the gastrointestinal tract remains a clinical challenge. Here the authors present a bio-adhesive liquid coacervate coating on the intestinal tract that acts as a flowable drug carrier, mediates the sustained release of diverse drugs, and potentially enhances therapeutic efficacy against gastrointestinal diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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