Nature Communications (Apr 2018)
Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
- Simone Joas,
- Erica H. Parrish,
- Clement W. Gnanadurai,
- Edina Lump,
- Christina M. Stürzel,
- Nicholas F. Parrish,
- Gerald H. Learn,
- Ulrike Sauermann,
- Berit Neumann,
- Kerstin Mätz Rensing,
- Dietmar Fuchs,
- James M. Billingsley,
- Steven E. Bosinger,
- Guido Silvestri,
- Cristian Apetrei,
- Nicolas Huot,
- Thalia Garcia-Tellez,
- Michaela Müller-Trutwin,
- Dominik Hotter,
- Daniel Sauter,
- Christiane Stahl-Hennig,
- Beatrice H. Hahn,
- Frank Kirchhoff
Affiliations
- Simone Joas
- Institute of Molecular Virology, Ulm University Medical Center
- Erica H. Parrish
- Departments of Medicine and Microbiology, University of Pennsylvania
- Clement W. Gnanadurai
- Institute of Molecular Virology, Ulm University Medical Center
- Edina Lump
- Institute of Molecular Virology, Ulm University Medical Center
- Christina M. Stürzel
- Institute of Molecular Virology, Ulm University Medical Center
- Nicholas F. Parrish
- Departments of Medicine and Microbiology, University of Pennsylvania
- Gerald H. Learn
- Departments of Medicine and Microbiology, University of Pennsylvania
- Ulrike Sauermann
- German Primate Centre
- Berit Neumann
- German Primate Centre
- Kerstin Mätz Rensing
- German Primate Centre
- Dietmar Fuchs
- Division of Biological Chemistry, Biocenter Innsbruck Medical University, Center for Chemistry and Biomedicine
- James M. Billingsley
- Emory Vaccine Center and Yerkes National Primate Research Center, Emory University
- Steven E. Bosinger
- Emory Vaccine Center and Yerkes National Primate Research Center, Emory University
- Guido Silvestri
- Emory Vaccine Center and Yerkes National Primate Research Center, Emory University
- Cristian Apetrei
- WA Center for Vaccine Research, University of Pittsburgh
- Nicolas Huot
- Institut Pasteur, Unité HIV, Inflammation and Persistence
- Thalia Garcia-Tellez
- Institut Pasteur, Unité HIV, Inflammation and Persistence
- Michaela Müller-Trutwin
- Institut Pasteur, Unité HIV, Inflammation and Persistence
- Dominik Hotter
- Institute of Molecular Virology, Ulm University Medical Center
- Daniel Sauter
- Institute of Molecular Virology, Ulm University Medical Center
- Christiane Stahl-Hennig
- German Primate Centre
- Beatrice H. Hahn
- Departments of Medicine and Microbiology, University of Pennsylvania
- Frank Kirchhoff
- Institute of Molecular Virology, Ulm University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-03762-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al. incorporate two putative HIV virulence factors into SIV and study effects in infected monkeys, suggesting that species-specific host factors are responsible for HIV pathogenesis.
