Easy access to medium-sized lactones through metal carbene migratory insertion enabled 1,4-palladium shift

Abstract

Transannular construction of medium-sized lactones is entropically unfavoured. Herein, the authors describe a strategy for valuable medium-sized lactone synthesis from available benzaldehydes by selective C-H bond functionalization via palladium carbene migratory insertion-enabled 1,4-palladium shift.