Nature Communications (Jun 2016)
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
- Rouven Hoefflin,
- Bernd Lahrmann,
- Gregor Warsow,
- Daniel Hübschmann,
- Cathleen Spath,
- Britta Walter,
- Xin Chen,
- Luisa Hofer,
- Stephan Macher-Goeppinger,
- Yanis Tolstov,
- Nina Korzeniewski,
- Anette Duensing,
- Carsten Grüllich,
- Dirk Jäger,
- Sven Perner,
- Gita Schönberg,
- Joanne Nyarangi-Dix,
- Sanjay Isaac,
- Gencay Hatiboglu,
- Dogu Teber,
- Boris Hadaschik,
- Sascha Pahernik,
- Wilfried Roth,
- Roland Eils,
- Matthias Schlesner,
- Holger Sültmann,
- Markus Hohenfellner,
- Niels Grabe,
- Stefan Duensing
Affiliations
- Rouven Hoefflin
- Department of Urology, Section of Molecular Urooncology, University of Heidelberg School of Medicine, Medical Faculty Heidelberg
- Bernd Lahrmann
- Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg
- Gregor Warsow
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Daniel Hübschmann
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Cathleen Spath
- Department of Medical Oncology, National Center for Tumor Diseases
- Britta Walter
- Department of Pathology, University of Heidelberg School of Medicine
- Xin Chen
- Department of Urology, Section of Molecular Urooncology, University of Heidelberg School of Medicine, Medical Faculty Heidelberg
- Luisa Hofer
- Department of Urology, University of Heidelberg School of Medicine
- Stephan Macher-Goeppinger
- Department of Pathology, University of Heidelberg School of Medicine
- Yanis Tolstov
- Department of Urology, Section of Molecular Urooncology, University of Heidelberg School of Medicine, Medical Faculty Heidelberg
- Nina Korzeniewski
- Department of Urology, Section of Molecular Urooncology, University of Heidelberg School of Medicine, Medical Faculty Heidelberg
- Anette Duensing
- University of Pittsburgh Cancer Institute, Cancer Therapeutics Program
- Carsten Grüllich
- Department of Medical Oncology, National Center for Tumor Diseases
- Dirk Jäger
- Department of Medical Oncology, National Center for Tumor Diseases
- Sven Perner
- Institute of Pathology, University Hospital Lübeck and Leibniz Research Center Borstel
- Gita Schönberg
- Department of Urology, University of Heidelberg School of Medicine
- Joanne Nyarangi-Dix
- Department of Urology, University of Heidelberg School of Medicine
- Sanjay Isaac
- Department of Medical Oncology, National Center for Tumor Diseases
- Gencay Hatiboglu
- Department of Urology, University of Heidelberg School of Medicine
- Dogu Teber
- Department of Urology, University of Heidelberg School of Medicine
- Boris Hadaschik
- Department of Urology, University of Heidelberg School of Medicine
- Sascha Pahernik
- Department of Urology, University of Heidelberg School of Medicine
- Wilfried Roth
- Department of Pathology, University of Heidelberg School of Medicine
- Roland Eils
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Matthias Schlesner
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Holger Sültmann
- Division of Cancer Genome Research, National Center for Tumor Diseases, German Cancer Research Center, German Cancer Consortium (DKTK)
- Markus Hohenfellner
- Department of Urology, University of Heidelberg School of Medicine
- Niels Grabe
- Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg
- Stefan Duensing
- Department of Urology, Section of Molecular Urooncology, University of Heidelberg School of Medicine, Medical Faculty Heidelberg
- DOI
- https://doi.org/10.1038/ncomms11845
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the tumour.
