烟雾病颅内外血管参数评估研究进展 Progress of Intracranial and Extracranial Vascular Parameters Evaluation in Moyamoya Disease

Abstract

烟雾病(moyamoya disease，MMD)的特征性病变为双侧颈内动脉终末段及大脑中动脉、大脑前动脉起始段进行性狭窄闭塞，导致脑缺血及缺血后脆弱的血管破裂引起脑出血。基于脑-颈血管一体化，颅外及颅内不同节段血流状态相互影响，可通过检测特定节段血流参数提示疾病发展进程，从而指导临床策略的选择。深入了解烟雾病不同节段血流状态及疾病发展进程对疾病诊疗有重要作用。本文对烟雾病颅外及颅内不同节段血管参数、侧支循环及其与临床预后的相关性进行综述，为后续针对颅内动脉狭窄或闭塞引起的缺血性及出血性相关脑血管病诊疗与研究提供参考。 Moyamoya disease (MMD) is characterized by progressive stenosis and occlusion of the terminals of bilateral internal carotid artery, the initial segment of middle cerebral artery and anterior cerebral artery, which leads to cerebral ischemia and hemorrhage due to fragile vessels rupture after ischemia. The blood flow of different segments of intracranial and extracranial vessels can influence each other, and the detection of blood flow parameters in specific segments can reveal the progression of disease, which can guide clinical decision making. It is important for diagnosis and treatment of MMD to understand and master blood flow changes of different segments and progression of MMD. This article reviewed the correlation of different extracranial and intracranial vascular parameters, collateral circulation and clinical prognosis of MMD, providing reference for the diagnosis and treatment of ischemic and hemorrhagic cerebrovascular diseases caused by intracranial artery stenosis or occlusion.

Keywords

• 烟雾病
• 颅内外血管参数
• 侧支循环
• 临床预后
• moyamoya disease
• intracranial and extracranial vascular parameter
• collateral circulation
• prognosis