Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis

Nicolas Rosewick; Keith Durkin; Maria Artesi; Ambroise Marçais; Vincent Hahaut; Philip Griebel; Natasa Arsic; Véronique Avettand-Fenoel; Arsène Burny; Carole Charlier; Olivier Hermine; Michel Georges; Anne Van den Broeke

doi:10.1038/ncomms15264

Nature Communications (May 2017)

Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis

Nicolas Rosewick,
Keith Durkin,
Maria Artesi,
Ambroise Marçais,
Vincent Hahaut,
Philip Griebel,
Natasa Arsic,
Véronique Avettand-Fenoel,
Arsène Burny,
Carole Charlier,
Olivier Hermine,
Michel Georges,
Anne Van den Broeke

Affiliations

Nicolas Rosewick: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Keith Durkin: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Maria Artesi: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Ambroise Marçais: Service d’hématologie, Hôpital Universitaire Necker, Université René Descartes, Assistance publique hôpitaux de Paris
Vincent Hahaut: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Philip Griebel: Vaccine and Infectious Disease Organization, VIDO-Intervac, University of Saskatchewan
Natasa Arsic: Vaccine and Infectious Disease Organization, VIDO-Intervac, University of Saskatchewan
Véronique Avettand-Fenoel: Laboratoire de Virologie, AP-HP, Hôpital Necker-Enfants Malades, Université Paris Descartes
Arsène Burny: Laboratory of Experimental Hematology, Institut Jules Bordet, Université Libre de Bruxelles (ULB)
Carole Charlier: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Olivier Hermine: Service d’hématologie, Hôpital Universitaire Necker, Université René Descartes, Assistance publique hôpitaux de Paris
Michel Georges: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)
Anne Van den Broeke: Unit of Animal Genomics, GIGA-R, Université de Liège (ULg)

DOI: https://doi.org/10.1038/ncomms15264
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Human T-cell leukaemia virus type-1 and bovine leukaemia virus infect T and B lymphocytes and lead to aggressive leukaemia. Here, the authors show these proviruses integrate near cancer drivers perturbing transcription termination or antisense RNA-dependent interaction, suggesting post-transcriptional mechanisms in some cases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal