PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Pojeong Park; John Georgiou; Thomas M. Sanderson; Kwang-Hee Ko; Heather Kang; Ji-il Kim; Clarrisa A. Bradley; Zuner A. Bortolotto; Min Zhuo; Bong-Kiun Kaang; Graham L. Collingridge

doi:10.1038/s41467-020-20523-3

Nature Communications (Jan 2021)

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Pojeong Park,
John Georgiou,
Thomas M. Sanderson,
Kwang-Hee Ko,
Heather Kang,
Ji-il Kim,
Clarrisa A. Bradley,
Zuner A. Bortolotto,
Min Zhuo,
Bong-Kiun Kaang,
Graham L. Collingridge

Affiliations

Pojeong Park: Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol
John Georgiou: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Thomas M. Sanderson: Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol
Kwang-Hee Ko: Department of Biological Sciences, College of Natural Sciences, Seoul National University
Heather Kang: Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol
Ji-il Kim: Department of Biological Sciences, College of Natural Sciences, Seoul National University
Clarrisa A. Bradley: Department of Biological Sciences, College of Natural Sciences, Seoul National University
Zuner A. Bortolotto: Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol
Min Zhuo: Department of Biological Sciences, College of Natural Sciences, Seoul National University
Bong-Kiun Kaang: Department of Biological Sciences, College of Natural Sciences, Seoul National University
Graham L. Collingridge: Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol

DOI: https://doi.org/10.1038/s41467-020-20523-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance, via insertion of calcium-permeable AMPA receptors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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