Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Abstract

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

Keywords

• salarins
• tulearins
• Fascaplysinopsis sp.
• sponge
• nitrogenous macrolide
• leukemia cells