Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

Taek-Chin Cheong; Mara Compagno; Roberto Chiarle

doi:10.1038/ncomms10934

Nature Communications (Mar 2016)

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

Taek-Chin Cheong,
Mara Compagno,
Roberto Chiarle

Affiliations

Taek-Chin Cheong: Department of Pathology, Children’s Hospital Boston and Harvard Medical School
Mara Compagno: Department of Pathology, Children’s Hospital Boston and Harvard Medical School
Roberto Chiarle: Department of Pathology, Children’s Hospital Boston and Harvard Medical School

DOI: https://doi.org/10.1038/ncomms10934
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal